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Related Concept Videos

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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Related Experiment Video

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An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
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Published on: February 1, 2019

Au25(SG)18 as a fluorescent iodide sensor.

Man Wang1, Zhikun Wu, Jiao Yang

  • 1Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanostructures, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, China.

Nanoscale
|April 24, 2012
PubMed
Summary

Gold nanoclusters (GNC) show promise as fluorescent sensors for detecting iodide ions. This study highlights their potential for sensitive and selective anion detection using a novel mechanism.

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Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Materials Science

Background:

  • Gold nanoclusters (GNC) are emerging nanomaterials with significant potential in basic science and applications.
  • Surface-induced fluorescence properties of GNCs are key to their sensing capabilities.

Purpose of the Study:

  • To investigate the use of Au(25)(SG)(18) (glutathione-stabilized gold nanoclusters) as a fluorescent sensor for iodide ions.
  • To explore the sensing mechanism and selectivity of Au(25)(SG)(18) for various anions.

Main Methods:

  • Utilized the surface-induced fluorescence of Au(25)(SG)(18) for sensing applications.
  • Tested the sensor's response to 12 different anions to determine selectivity.
  • Characterized the sensing mechanism, termed affinity-induced ratiometric and enhanced fluorescence (AIREF).

Main Results:

  • Au(25)(SG)(18) demonstrated good selectivity for iodide ions among 12 tested anions.
  • A detection limit of 400 nM for iodide was achieved, with potential for enhancement.
  • The novel AIREF sensing mechanism was identified and characterized.

Conclusions:

  • Au(25)(SG)(18) is a promising candidate for sensitive and selective fluorescent iodide sensing.
  • The AIREF mechanism offers a new strategy for developing nanoparticle-based sensors.
  • Further optimization could improve the detection limit for iodide sensing.