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Testosterone and cardiovascular disease in men

Paul D Morris1, Kevin S Channer

  • 1Sheffield Teaching Hospital NHS Trust, Sheffield, UK.

Asian Journal of Andrology
|April 24, 2012
PubMed

Insights

Men face higher risks for coronary artery disease (CAD) due to testosterone effects. This review explores testosterone

Area of Science:

  • Cardiovascular Endocrinology
  • Men's Health
  • Hormone Therapy

Background:

  • Men exhibit higher coronary artery disease (CAD) prevalence and mortality compared to women.
  • Sex hormones, particularly testosterone, are implicated in this gender disparity.
  • Age-related decline in testosterone is a significant factor in men's cardiovascular health.

Purpose of the Study:

  • To review current evidence on the cardiovascular effects of testosterone in men.
  • To examine the relationship between testosterone levels, coronary disease, risk factors, and mortality.
  • To discuss the therapeutic applications and controversies surrounding testosterone replacement therapy (TRT).

Main Methods:

  • Literature review of existing studies on testosterone and cardiovascular health.
  • Analysis of the vaso-active properties of testosterone.
  • Examination of the 'cause versus effect' debate regarding testosterone levels in men with CAD.

Main Results:

  • Testosterone influences cardiovascular health through various mechanisms, including vaso-activity.
  • Low testosterone levels are observed in men with coronary heart disease, though causality is debated.
  • Potential benefits of TRT in men with heart failure and angina are discussed, alongside safety concerns.

Conclusions:

  • Testosterone plays a complex role in male cardiovascular health and CAD.
  • Further research is needed to clarify the causal relationship between testosterone levels and heart disease.
  • The role of screening for and treating hypogonadism with TRT in men with heart disease warrants careful consideration.

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