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Testosterone and cardiovascular disease in men.
Paul D Morris1, Kevin S Channer
1Sheffield Teaching Hospital NHS Trust, Sheffield, UK.
Asian Journal of Andrology
|April 24, 2012
Summary
Men face higher risks for coronary artery disease (CAD) due to testosterone effects. This review explores testosterone
Area of Science:
- Cardiovascular Endocrinology
- Men's Health
- Hormone Therapy
Background:
- Men exhibit higher coronary artery disease (CAD) prevalence and mortality compared to women.
- Sex hormones, particularly testosterone, are implicated in this gender disparity.
- Age-related decline in testosterone is a significant factor in men's cardiovascular health.
Purpose of the Study:
- To review current evidence on the cardiovascular effects of testosterone in men.
- To examine the relationship between testosterone levels, coronary disease, risk factors, and mortality.
- To discuss the therapeutic applications and controversies surrounding testosterone replacement therapy (TRT).
Main Methods:
- Literature review of existing studies on testosterone and cardiovascular health.
- Analysis of the vaso-active properties of testosterone.
- Examination of the 'cause versus effect' debate regarding testosterone levels in men with CAD.
Main Results:
- Testosterone influences cardiovascular health through various mechanisms, including vaso-activity.
- Low testosterone levels are observed in men with coronary heart disease, though causality is debated.
- Potential benefits of TRT in men with heart failure and angina are discussed, alongside safety concerns.
Conclusions:
- Testosterone plays a complex role in male cardiovascular health and CAD.
- Further research is needed to clarify the causal relationship between testosterone levels and heart disease.
- The role of screening for and treating hypogonadism with TRT in men with heart disease warrants careful consideration.
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