Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progression through the cell cycle: an overview.

J L Fridovich-Keil1, L J Hansen, K Keyomarsi

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

The American Review of Respiratory Disease
|December 1, 1990
PubMed
Summary

Tissue size is regulated by cellular synthetic and degradative processes. Novel proteins are being discovered that play key roles in regulating cell proliferation and tissue homeostasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Not-so-frequent flyers? Restricted avian dispersal of <i>Diplostomum</i> parasites across North Atlantic islands.

Journal of helminthology·2026
Same author

Efficacy and acceptability of psychosocial interventions in asylum seekers and refugees: systematic review and meta-analysis.

Epidemiology and psychiatric sciences·2019
Same author

Drosophila melanogaster Models of Galactosemia.

Current topics in developmental biology·2017
Same author

PKCiota promotes ovarian tumor progression through deregulation of cyclin E.

Oncogene·2015
Same author

The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.

Oncogene·2014
Same author

Structured personal care of type 2 diabetes: a 19 year follow-up of the study Diabetes Care in General Practice (DCGP).

Diabetologia·2013

Area of Science:

  • Cell biology
  • Molecular biology
  • Physiology

Background:

  • Tissue mass is regulated by a balance between synthesis and degradation at cellular and molecular levels.
  • Physiologic and pathologic conditions can disrupt this balance, leading to tissue size changes.
  • Cell proliferation must be strictly regulated to meet organismal needs, with defects implicated in disease.

Purpose of the Study:

  • To provide an overview of molecular mechanisms regulating tissue homeostasis and cell proliferation.
  • To highlight recent discoveries of novel proteins involved in these regulatory processes.
  • To illustrate the role of the cell cycle in controlling molecular events.

Main Methods:

  • Review of recent discoveries in cell biology and molecular regulation.

Related Experiment Videos

  • Examples drawn from mammalian fibroblasts and yeast models.
  • Focus on novel proteins with regulatory roles in cell proliferation.

    • Main Results:

    • Identified two classes of molecules: housekeeping and regulatory (e.g., growth factors, signal transduction molecules).
    • Cell cycle provides a framework for understanding molecular events in proliferation.
    • Recent discoveries point to novel proteins with significant regulatory functions.

    Conclusions:

    • Understanding the molecular basis of cell proliferation is crucial for comprehending tissue homeostasis.
    • Novel proteins are emerging as key players in regulating cell cycle and tissue dynamics.
    • Continued research, utilizing diverse model systems, is essential for uncovering these regulatory mechanisms.