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Related Experiment Videos

Growth factor-regulated pathways in epithelial cell proliferation.

S A Aaronson1, J S Rubin, P W Finch

  • 1Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.

The American Review of Respiratory Disease
|December 1, 1990
PubMed
Summary
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Researchers identified erbB-3, a new member of the epidermal growth factor receptor family. Elevated erbB-3 expression may contribute to epithelial cancers, highlighting its role in cell proliferation and malignancies.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • Epithelial cell proliferation is regulated by two main growth-factor signaling pathways.
  • Epidermal Growth Factor Receptor (EGFR) family members, like erbB/EGFR and erbB-2, are implicated in epithelial malignancies.
  • Oncogenes in these pathways can override normal growth factor requirements.

Purpose of the Study:

  • To identify novel members of the EGFR family involved in epithelial cell growth.
  • To investigate the potential role of newly identified receptors in epithelial cancers.

Main Methods:

  • Reduced stringency hybridization using v-erbB as a probe.
  • cDNA cloning and sequence analysis.
  • Analysis of erbB-3 mRNA expression levels in normal tissues and tumor cell lines.

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Main Results:

  • A third member of the EGFR family, designated erbB-3, was identified.
  • cDNA cloning revealed erbB-3 encodes a 148-kD transmembrane protein similar to EGFR.
  • Normal erbB-3 expression observed in keratinocytes and glandular epithelium.
  • Markedly elevated erbB-3 mRNA levels detected in specific mammary tumor cell lines.

Conclusions:

  • erbB-3 is a novel EGFR family member with a potential physiologic role in keratinocytes and glandular epithelium.
  • Increased erbB-3 expression may be involved in the development of certain human epithelial malignancies.
  • Further research into erbB-3's function in cancer is warranted.