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Endocrinological responses to 5-HT.

P J Cowen¹, I M Anderson, S E Gartside

¹MRC Clinical Pharmacology Unit, Littlemore Hospital, Oxford, England.

Annals of the New York Academy of Sciences

|January 1, 1990

Summary

Neuroendocrine and temperature responses in humans reveal the roles of serotonin (5-HT) receptor subtypes. Research indicates 5-HT1A and 5-HT2/1C receptors influence prolactin and ACTH, with potential dual roles in hormone secretion.

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Area of Science:

Neuroendocrinology
Pharmacology
Human Physiology

Background:

Neuroendocrine and temperature responses in humans offer insights into serotonin (5-HT) receptor subtype function.
Previous research suggests specific 5-HT receptor subtypes mediate various hormonal responses, including prolactin (PRL) and adrenocorticotropic hormone (ACTH) secretion.

Purpose of the Study:

To explore the involvement of different 5-HT receptor subtypes in human neuroendocrine and temperature regulation.
To clarify the specific roles of 5-HT1A and 5-HT2/1C receptors in PRL, ACTH, and growth hormone (GH) secretion.
To investigate the differential effects of 5-HT receptor agonists on human body temperature.

Main Methods:

Utilizing human neuroendocrine and temperature responses as indicators of 5-HT receptor sensitivity.
Examining the effects of various challenges to 5-HT function (e.g., LTP, fenfluramine) on hormonal release.
Comparing the actions of selective 5-HT receptor agonists and antagonists on hormonal and temperature regulation.

Main Results:

Evidence suggests 5-HT1A receptors may mediate PRL response to LTP, while 5-HT2/1C receptors likely increase both PRL and ACTH.
Both 5-HT1A and 5-HT2/1C receptors appear to facilitate ACTH release in humans, indicating a dual control mechanism.
5-HT1A receptors may play a more significant role in GH secretion, and 5-HT1A and 5-HT2 agonists can have opposing effects on body temperature.

Conclusions:

Human neuroendocrine and temperature responses are valuable tools for studying 5-HT receptor function.
Further research with selective 5-HT receptor ligands is crucial to fully elucidate the complex roles of these receptors in human physiology.
Understanding the dual control of ACTH and PRL release by 5-HT1A and 5-HT2/1C receptors requires further investigation.

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