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Updated: May 23, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Posterior circulation embolism as a potential mechanism for migraine with aura
Dong Hoon Shin1, Tae Sung Lim, Seok Woo Yong
1Ajou University School of Medicine, South Korea.
Background:
Although the mechanism of migraine is regarded as a functional disorder of the brain, numerous studies have reported that migraine is closely associated with vascular system abnormalities.
Case Reports:
We describe a 19-year-old female with recurrent migraine attacks and typical aura for 7 years. MRI showed multiple stroke lesions in the posterior circulation. Moreover, a pseudoaneurysm (1.9 × 1.4 cm) originating from the left vertebral artery was observed on four-vessel angiography. Multiple microembolic signals (MES) were repeatedly observed in the basilar artery using 30-minute transcranial Doppler monitoring. Interestingly, MES and her typical migrainous symptoms disappeared simultaneously with removal of the pseudoaneurysm.
Discussion:
This case supports the fact that microemboli play a pivotal role in the development of migraine attacks.
Insights
Migraine attacks may be caused by microemboli, which are small clots. A patient
Area of Science:
- Neurology
- Vascular Medicine
Background:
- Migraine is often considered a functional brain disorder.
- However, research suggests a strong link between migraine and vascular system abnormalities.
- The precise mechanisms underlying migraine pathophysiology remain under investigation.
Observation:
- A 19-year-old female experienced 7 years of recurrent migraine with aura.
- Cerebral MRI revealed multiple posterior circulation stroke lesions.
- Four-vessel angiography identified a 1.9 × 1.4 cm left vertebral artery pseudoaneurysm.
Findings:
- Transcranial Doppler monitoring detected multiple microembolic signals (MES) in the basilar artery.
- MES and migraine symptoms resolved concurrently with pseudoaneurysm treatment.
- This suggests a direct correlation between the pseudoaneurysm, microemboli, and migraine.
Implications:
- This case highlights the potential role of microemboli in migraine development.
- Vascular abnormalities, such as pseudoaneurysms, may be a source of embolic material.
- Further research into vascular causes of migraine is warranted.
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