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Updated: May 23, 2026
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Variation in reported neonatal group B streptococcal disease incidence in developing countries
Alemnew F Dagnew1, Marianne C Cunnington, Queen Dube
1Immunology and Parasitology, Department of Microbiology, College of Health Sciences, Mekelle University, Ethiopia.
Summary
Group B Streptococcus (GBS) causes neonatal sepsis. Data from developing nations is limited, showing varied GBS incidence rates and potential under-ascertainment, necessitating better surveillance for interventions.
Area of Science:
- Neonatal health
- Infectious disease epidemiology
- Microbiology
Background:
- Group B Streptococcus (GBS) is a primary cause of neonatal sepsis in developed nations.
- The epidemiological burden of GBS in developing countries remains poorly understood.
- Accurate incidence data is crucial for targeted public health interventions.
Purpose of the Study:
- To assess the incidence of neonatal GBS disease in developing countries.
- To identify limitations in current GBS surveillance methods in these regions.
- To highlight the need for improved data collection for intervention planning.
Main Methods:
- Systematic literature review of 5 databases.
- Inclusion of studies reporting neonatal GBS disease incidence from developing countries.
- Assessment of case ascertainment and culture methodologies.
Main Results:
- Only 20 relevant studies were identified.
- Neonatal GBS incidence varied from 0-3.06 per 1000 live births across regions.
- Most studies focused on hospital births, potentially missing community cases; automated methods yielded higher incidence.
Conclusions:
- Significant gaps exist in understanding the neonatal GBS disease burden in developing countries.
- Current surveillance methods may lead to under-ascertainment of GBS cases.
- Prospective, population-based surveillance is essential for accurate assessment and effective intervention design, including vaccine development.
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