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Serotonin and appetite.

G Curzon1

  • 1Institute of Neurology, Queen Square, London, England.

Annals of the New York Academy of Sciences
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Serotonin (5-HT) receptor subtypes play a role in appetite regulation. Agonists targeting 5-HT1A receptors increase food intake, while those targeting 5-HT1B and 5-HT1C receptors decrease it, particularly in females.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Serotonin (5-HT) influences feeding behavior, with potential roles in appetite termination and disorders.
  • The discovery of diverse 5-HT receptor subtypes necessitates investigation into their specific functions in feeding control.

Purpose of the Study:

  • To investigate the involvement of specific serotonin (5-HT) receptor subtypes in the pharmacological regulation of feeding behavior.
  • To elucidate the mechanisms by which 5-HT receptor agonists and antagonists modulate food intake.

Main Methods:

  • Administered various 5-HT receptor agonists (e.g., 8-OHDPAT, buspirone, RU 24969, mCPP, TFMPP) and antagonists to rats under different feeding conditions (freely feeding vs. food-deprived).
  • Assessed effects on food intake, including macronutrient selection (carbohydrate vs. protein).

Related Experiment Videos

  • Investigated the role of specific brain regions, such as the paraventricular nucleus of the hypothalamus, by direct infusion of compounds.

    • Main Results:

    • 5-HT1A receptor agonists (e.g., 8-OHDPAT) stimulated food intake in freely feeding rats, likely via autoreceptor activation reducing 5-HT release.
    • 5-HT1B and/or 5-HT1C receptor agonists (RU 24969, mCPP, TFMPP) decreased food intake in food-deprived rats.
    • Hypophagia induced by RU 24969 was linked to 5-HT1B receptors, while mCPP and TFMPP effects involved both 5-HT1C and 5-HT1B receptors.
    • Direct infusion into the paraventricular nucleus confirmed its role in mediating hypophagia.
    • Hypophagic effects were more pronounced in female rats.

    Conclusions:

    • Specific serotonin (5-HT) receptor subtypes differentially regulate feeding behavior.
    • 5-HT1A receptor activation promotes feeding, whereas 5-HT1B and 5-HT1C receptor activation suppresses appetite.
    • The paraventricular nucleus is a key brain region for 5-HT-mediated appetite control.
    • Sex differences in response to 5-HTergic drugs suggest potential relevance for human anorexia.