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Serotonin in human eating disorders.

D C Jimerson1, M D Lesem, A P Hegg

  • 1Department of Psychiatry, Beth Israel Hospital, Boston, Massachusetts 02215.

Annals of the New York Academy of Sciences
|January 1, 1990
PubMed
Summary
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Neurotransmitter dysregulation, particularly serotonin, may influence binge eating in eating disorders like anorexia nervosa and bulimia nervosa. Further research is needed to understand these complex conditions.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Eating disorders, including anorexia nervosa and bulimia nervosa, present complex symptomatology.
  • The pathophysiology is unlikely attributable to a single neurotransmitter system.
  • Preliminary evidence suggests a role for neurotransmitter dysregulation.

Purpose of the Study:

  • To review evidence on the role of neurotransmitter systems in eating disorders.
  • To explore the contribution of serotonin function to binge eating episodes.
  • To identify future research directions.

Main Methods:

  • Literature review of studies on eating disorders and neurotransmitter function.
  • Analysis of preliminary findings linking serotonin to binge eating.

Related Experiment Videos

  • Consideration of patient subgroups (e.g., low weight with bulimic symptoms).

    • Main Results:

    • Decreased central serotonin function may contribute to binge eating in bulimia nervosa and related conditions.
    • Serotonin dysregulation is a potential factor in the onset and persistence of binge eating.
    • The complexity of eating disorders suggests multifactorial pathophysiology.

    Conclusions:

    • Serotonin system dysfunction is implicated in binge eating episodes within eating disorders.
    • Future research should utilize selective serotonin receptor agents.
    • Longitudinal studies are crucial to disentangle neurotransmitter, dietary, and weight influences.