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Updated: May 23, 2026

Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
Formulation development and evaluation of alginate microspheres of Ibuprofen
M Nagpal1, Dk Maheshwari, P Rakha
1Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, India.
Abstract:
The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. Eight batches of microspheres (F1-F8) were prepared by applying 2(3) factorial design. The amount of sodium alginate, amount of calcium chloride, and amount of magnesium stearate were selected as formulation variables. All the batches were evaluated in terms of percentage yield, percentage encapsulation efficiency and in vitro release characteristics. The batch F7 was found to be optimum batch and was further characterized via scanning electron microscopy (SEM) and particle size analysis. Multiple linear regression was applied to confirm significant effect of each variable on release characteristics. The model developed in the present study can be effectively utilized to achieve the formulation with desired release characteristics.
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