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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Updated: May 23, 2026

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

MicroRNAs in Neurotoxicity.

Prameet Kaur1, Arunmozhiarasi Armugam, Kandiah Jeyaseelan

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597.

Journal of Toxicology
|April 24, 2012
PubMed
Summary

MicroRNAs (miRNAs) regulate gene expression and cellular events. Their dysregulation can lead to neurotoxicity, contributing to diseases like Parkinson's and Alzheimer's.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing cellular functions.
  • Dysregulation of neuronal activity by miRNAs can cause detrimental substance accumulation, leading to neurotoxicity.
  • Neurotoxicity is implicated in debilitating neurological conditions such as Parkinson's and Alzheimer's disease.

Purpose of the Study:

  • To explore the role of microRNAs in neuronal pathophysiological conditions.
  • To highlight the significance of understanding miRNA expression in neurotoxicity.
  • To discuss how dysregulated miRNAs contribute to neurological diseases.

Main Methods:

  • Literature review on microRNA function and neurotoxicity.
  • Analysis of the link between miRNA dysregulation and specific neurological disorders.

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  • Discussion of factors contributing to neurotoxicity, including genetic predisposition and external agents.

    • Main Results:

    • MicroRNAs play a pivotal role in modulating neuronal activities and gene expression.
    • Dysregulated miRNAs can lead to neurotoxic conditions, impacting physiological processes.
    • Evidence suggests miRNAs are involved in the pathogenesis of neurodegenerative diseases.

    Conclusions:

    • Understanding microRNA expression is crucial for comprehending neurotoxicity.
    • Dysregulated microRNAs are implicated in various neuronal pathophysiological conditions.
    • Further research into miRNAs may offer insights into treating neurological diseases.