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TumorHoPe: a database of tumor homing peptides

Pallavi Kapoor1, Harinder Singh, Ankur Gautam

  • 1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, India.

Plos One
|April 24, 2012
PubMed
Abstract

Insights

TumorHoPe is a new database of tumor homing peptides, offering valuable information for developing targeted cancer therapies. This resource aids in designing effective peptide-based drugs and drug delivery systems.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Oncology

Background:

  • Cancer poses a significant global health and economic challenge, necessitating targeted therapeutic strategies.
  • Developing drugs that selectively target tumor cells over normal cells is a critical unmet need.
  • Tumor homing peptides offer a promising approach for specific drug delivery to tumor tissues.

Purpose of the Study:

  • To create a comprehensive, manually curated database of experimentally validated tumor homing peptides.
  • To provide a valuable resource for researchers in cancer drug development and delivery.
  • To facilitate the design of novel peptide-based therapeutics.

Main Methods:

  • Compiled tumor homing peptides from scientific literature, patents, and existing databases.
  • Manually curated data for experimental validation and specificity towards tumor cells and microenvironment.
  • Integrated web-based tools for searching and analyzing peptide properties, including sequence, target, and motifs.

Main Results:

  • The TumorHoPe database contains 744 experimentally validated tumor homing peptides.
  • Peptides target diverse tumor types including breast, lung, and prostate cancer.
  • Identified common tumor-targeting motifs such as RGD and NGR, crucial for recognizing angiogenic markers.

Conclusions:

  • TumorHoPe is a unique, freely accessible database for experimentally validated tumor homing peptides.
  • The database provides comprehensive information essential for designing targeted peptide-based drugs and delivery systems.
  • This resource will significantly aid the scientific community in advancing cancer therapy research.

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