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Updated: May 23, 2026

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Congenital adrenal hyperplasia.

Cleo Dessinioti¹, Andreas Katsambas

¹Department of Dermatology; Andreas Sygros Hospital; University of Athens; Athens, Greece.

Dermato-Endocrinology

|April 24, 2012

Summary

Congenital adrenal hyperplasia (CAH) encompasses inherited disorders of cortisol and aldosterone synthesis, often leading to androgen excess. This review focuses on CAH

Area of Science:

Endocrinology
Genetics
Dermatology

Background:

Congenital adrenal hyperplasia (CAH) comprises inherited disorders stemming from enzymatic defects in cortisol and/or aldosterone biosynthesis.
These defects result in glucocorticoid deficiency, mineralocorticoid deficiency, and androgen excess, with 95% of cases caused by 21-hydroxylase deficiency.
CAH presents in classical (severe) and non-classical (milder) forms, impacting the pilosebaceous unit and causing skin issues.

Purpose of the Study:

To review the evaluation of patients with suspected CAH.
To detail the clinical presentation of CAH forms, emphasizing cutaneous manifestations.
To discuss available treatment options for CAH.

Main Methods:

Literature review of congenital adrenal hyperplasia.

Keywords:

acne congenital adrenal hyperplasia hirsutism

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Analysis of clinical presentations and diagnostic challenges.

Summary of current therapeutic strategies.

Main Results:

CAH is characterized by hormonal deficiencies and androgen excess.
Cutaneous manifestations like acne, alopecia, and hirsutism are common, particularly in non-classical CAH (NCAH).
Differential diagnosis between NCAH and polycystic ovary syndrome can be challenging.

Conclusions:

Androgen excess in CAH significantly impacts skin health.
Accurate diagnosis and management are crucial for addressing hormonal imbalances and associated symptoms.
Further research may improve the differentiation between NCAH and similar conditions.