Related Experiment Video
Updated: May 23, 2026
09:48
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Brain metastases from endometrial carcinoma
1Department of Obstetrics and Gynecology, Sapir Medical Center, Sackler School of Medicine, University of Tel-Aviv, Kfar Saba 44281, Israel.
ISRN Oncology
|April 24, 2012
Summary
Brain metastases from endometrial carcinoma are rare but serious, often occurring in advanced stages. Multimodal therapy, including surgery and radiotherapy, significantly improves survival compared to radiotherapy alone.
Area of Science:
- Neurology
- Oncology
- Gynecology
Background:
- Brain metastases from endometrial carcinoma are infrequently documented, accounting for 0.6% of cases.
- Endometrial carcinoma presenting with brain metastasis is typically advanced-stage and high-grade.
Purpose of the Study:
- To consolidate existing knowledge on brain metastases from endometrial carcinoma.
- To analyze incidence, clinical characteristics, and treatment outcomes.
Main Methods:
- Literature review of 115 documented cases of brain metastases from endometrial carcinoma.
- Analysis of patient demographics, tumor characteristics, metastasis patterns, and treatment modalities.
Main Results:
- Brain metastases occurred in 0.6% of endometrial carcinoma patients, usually in advanced-stage disease.
- Metastases were diagnosed a median of 17 months after initial diagnosis, often affecting the cerebrum.
- Multimodal therapy (surgery/radiosurgery + WBRT + chemotherapy) improved survival over WBRT alone.
Conclusions:
- Brain imaging should be routine in endometrial carcinoma follow-up.
- Endometrial biopsy is recommended for women with unknown primary brain metastases.
- Multimodal therapy offers better outcomes for brain metastases from endometrial carcinoma.
