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Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population?
Han-Sung Kwon1, In-Sook Sohn, Han-Sung Hwang
1Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Graduate School of Medicine, Yonsei University, and Yonsei University Health System, Seoul, Republic of Korea.
Objective:
To examine whether the distribution of genotypic and allelic frequencies of ICAM-1 K469 of Korean women with preeclampsia are different from that of a control group.
Study Design:
In this case-control study the ICAM-1 K469E polymorphism was genotyped in 42 women with preeclampsia and 138 normotensive controls who had delivered at least two normal, term infants. A direct sequencing reaction method was used to detect a single nucleotide polymorphism.
Results:
The distribution of genotype frequencies and the frequency of the K469 allele of the preeclampsia group were not significantly different from those of the controls. A similar trend was observed between the severe preeclampsia patients and the controls.
Conclusion:
The frequencies of the KK genotype and the K allele were higher in the preeclampsia group than those in the control group. However, there was no statistically significant difference.
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