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Updated: May 23, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity
Alberto Montesanto1, Serena Dato1, Dina Bellizzi1
1Department of Cell Biology, University of Calabria, Ponte Pietro Bucci cubo 4 C, 87036 Rende, CS, Italy.
Abstract:
Healthy ageing and longevity in humans result from a number of factors, including genetic background, favorable environmental and social factors and chance.In this article we aimed to overview the research on the biological basis of human healthy ageing and longevity, discussing the role of epidemiological, genetic and epigenetic factors in the variation of quality of ageing and lifespan, including the most promising candidate genes investigated so far. Moreover, we reported the methodologies applied for their identification, discussing advantages and disadvantages of the different approaches and possible solutions that can be taken to overcome them. Finally, we illustrated the recent approaches to define healthy ageing and underlined the role that the emerging field of epigenetics is gaining in the search for the determinants of healthy ageing and longevity.
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