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Updated: May 23, 2026

Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
Published on: June 23, 2023
Application of mid-infrared spectroscopy to the development and transfer of a manufacturing process for an active
Ian M Clegg1, Adrian M Daly, Craig Donnelly
1Analytical Development, PTx Pharmaceutical Sciences, Pfizer World Wide Research and Development, Sandwich Laboratories, Sandwich, Kent, CT13 9NJ, UK. ian.clegg@novartis.com
Abstract:
The use of in situ mid-infrared spectroscopy to support the development of a pharmaceutical manufacturing process is disclosed. Data on this two-stage telescoped reaction from several reaction scales (<50 mL to 1600 liters) and at multiple manufacturing locations is shown. In addition to providing data on both reactions in the telescope, the mid-IR data has been used to monitor an intermediate distillation operation and therefore it has been possible to profile the whole process. Data is also shown on aliquot addition during the first chemical transformation, which is used to check the instrumentation.
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