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Updated: May 23, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways
Alexander Hergovich1, Brian A Hemmings
1UCL Cancer Institute, University College London, London, United Kingdom. a.hergovich@ucl.ac.uk
Abstract:
Over the past decade Hippo kinase signalling has been established as an essential tumour suppressor pathway controlling tissue growth in flies and mammals. All members of the Hippo core signalling cassette are conserved from yeast to humans, whereby the yeast analogues of Hippo, Mats and Lats are central components of the mitotic exit network and septation initiation network in budding and fission yeast, respectively. Here, we discuss how far core Hippo signalling components in Drosophila melanogaster and mammals have reported similar mitotic functions as already established for their highly conserved yeast counterparts.
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