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Updated: May 22, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides
Cristina Chamorro1, Marcel A Boerman, Christopher J Arnusch
1Department of Medicinal Chemistry and Chemical Biology, Utrecht University, Utrecht, The Netherlands.
Abstract:
In order to enhance the membrane disruption of antimicrobial peptides both targeting and multivalent presentation approaches were explored. The antimicrobial peptides anoplin and temporin L were conjugated via click chemistry to vancomycin and to di- and tetravalent dendrimers. The vancomycin unit led to enhanced membrane disruption of large unilamellar vesicles (LUVs) displaying the vancomycin target lipid II, but only for temporin L and not for anoplin. The multivalent presentation led to enhanced LUV membrane disruption in the case of anoplin but not for temporin L.
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