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Updated: May 22, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

[Burkitt's lymphoma].

Nelea Afanas¹, Marisa Carvalho, Marta Almeida

¹Serviço de Pediatria, Hospital São Teotónio, Viseu, Portugal.

Acta Medica Portuguesa

|April 25, 2012

Summary

This summary is machine-generated.

This study analyzed 21 children with Burkitt

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Last Updated: May 22, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Area of Science:

Hematology
Pediatric Oncology
Cancer Genetics

Context:

Burkitt's lymphoma (BL) is an aggressive B-cell neoplasm.
Early diagnosis and treatment are critical for managing BL.
Understanding BL presentation in children is essential for effective care.

Purpose:

To describe and analyze the diagnosis, treatment, and outcomes of pediatric Burkitt's lymphoma.
To evaluate the diagnostic methods and treatment strategies employed over a ten-year period.
To assess the overall survival rates and identify factors influencing outcomes in pediatric BL cases.

Summary:

A retrospective analysis of 21 pediatric Burkitt's lymphoma cases (1998-2008) revealed a median age of seven years and a mean diagnostic delay of 20.8 days.
Abdominal masses were the most frequent presentation (13 cases), with diagnosis confirmed via biopsy in most instances.
Despite advanced stages (II-IV) and involvement of bone marrow (29%) and CNS (19%), the overall survival rate was 100%, with one relapsed case successfully treated with Rituximab and stem cell transplantation.

Impact:

This study highlights the importance of prompt diagnosis and multidisciplinary treatment approaches in achieving high survival rates for pediatric Burkitt's lymphoma.
The findings underscore the effectiveness of modern treatment protocols, including targeted therapies and stem cell transplantation, in managing relapsed cases.
Provides valuable data for refining clinical management strategies and improving outcomes for children diagnosed with Burkitt's lymphoma.