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Updated: May 22, 2026
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity
S Barmaki1, S Bohlooli, F Khoshkhahesh
1Islamic Azad University-Ardabil branch, Ardabil, Iran.
Aim:
The aim of this study was to evaluate effect of 10-day methylsulfonylmethane (MSM) supplementation on exercise-induced muscle damage.
Methods:
Eighteen healthy, non-smoking, active young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (M) (N.=9) and placebo (P) (N.=9). Subjects consumed daily either placebo (200 mL water) or MSM supplement (50 mg/kg MSM in 200 mL water) for 10 days. Afterward, participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, 30 min, 2, 24 and 48 h after exercise.
Results:
CK and bilirubin significantly increased in P group 24 h after exercise compared to M group (P=0.041 and P=0.002, respectively). TAC increased immediately post, 30 min, 2 and 24 h after exercise just in M group (P<0.05). TAC showed significant increase in M group 2 and 24 h after exercise compared to P group (P=0.014 and P=0.033, respectively).
Conclusion:
It seems that 10-day supplementation with MSM has allowed to decrease muscle damage via effect on antioxidant capacity.
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