Related Experiment Video
Updated: May 22, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
Critical episodes in the understanding and control of epidemic meningococcal meningitis
Andrew W Artenstein1, F Marc LaForce
1Department of Medicine, Memorial Hospital of Rhode Island and the Warren Alpert Medical School of Brown University, Providence, RI 02860, USA. artenstein@brown.edu
Abstract:
Epidemic meningococcal meningitis continues to be an important worldwide cause of morbidity and mortality, especially in developing countries. Throughout its relatively brief history, especially over the past century, a number of 'critical episodes' have occurred that have enhanced our understanding of the disease and allowed for its potential control. This article reviews three such 'episodes': the first effective treatment for the disease; the development of the first effective meningococcal vaccine; and the description of its epidemiology in sub-Saharan Africa, where the majority of epidemic meningococcal disease continues to occur. These historical 'episodes' have informed current strategies that may lead to eventual control of epidemic meningococcal meningitis.
Insights
Epidemic meningococcal meningitis remains a significant global health threat. Historical advancements in treatment, vaccination, and understanding its epidemiology in Africa offer hope for future control.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Meningococcal meningitis is a major cause of illness and death globally, particularly in developing nations.
- Understanding historical breakthroughs is crucial for controlling the disease.
Observation:
- Key historical events include the development of the first effective treatment.
- The creation of the first effective meningococcal vaccine marked a significant milestone.
- Epidemiological studies in sub-Saharan Africa highlighted the disease's burden in this region.
Findings:
- These critical episodes have significantly advanced the understanding and management of meningococcal meningitis.
- The disease's epidemiology is most pronounced in sub-Saharan Africa, a focal point for research and intervention.
Implications:
- Historical insights continue to shape current strategies for controlling epidemic meningococcal meningitis.
- Continued research and application of past lessons are vital for eventual disease eradication.
More Related Videos
Related Concept Videos
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Viral Meningitis
Mechanism of Antibiotic Resistance in MRSA
Infectious Diseases and Their Occurrence
Encephalitis l: Introduction

