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Biocompatible coatings with high albumin affinity
C C Tsai1, H H Huo, P Kulkarni
1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235.
ASAIO Transactions
|July 1, 1990
Summary
A new biocompatible silicone rubber (SR) film enhances albumin affinity for medical devices. This surface modification improves protein adsorption, benefiting blood-contacting applications.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Medical Device Engineering
Background:
- Silicone rubber (SR) is widely used in medical devices but can elicit adverse biological responses.
- Improving the biocompatibility of SR by enhancing specific protein interactions is crucial for advanced medical applications.
- Current surface modification techniques for SR often lack specificity or durability.
Purpose of the Study:
- To develop a novel biocompatible film coating for medical devices based on silicone rubber (SR).
- To enhance the albumin affinity of the SR surface for improved hemocompatibility.
- To investigate two specific surface modifications: hydroxyl (OH) and 16-carbon acyl (C16) group incorporation.
Main Methods:
- Development of two SR polymer forms with surface hydroxyl (OH) or acyl (C16) groups via oxymercuration/demercuration or hydroboration.
- Characterization of film surface morphology using Scanning Electron Microscopy (SEM).
- Analysis of surface chemistry using Attenuated Total Reflectance/Fourier Transform Infrared (ATR/FTIR) spectroscopy and water contact angle measurements.
- Assessment of albumin and fibrinogen adsorption and retention kinetics and isotherms.
Main Results:
- SEM confirmed smooth, uniform, and featureless film surfaces.
- ATR/FTIR and contact angle measurements verified the presence of surface OH groups and suggested acyl group presence.
- Albumin adsorption and retention were significantly enhanced at low concentrations (5% yield) of surface OH and C16 groups.
- Surface modification improved albumin affinity markedly, without affecting fibrinogen affinity, as indicated by adsorption studies.
Conclusions:
- A simple immersion process allows durable coating of complex medical devices with a biocompatible SR film.
- Surface hydroxylation and C16 acylation significantly enhance albumin affinity, offering a promising strategy for blood-contacting devices.
- This modified SR film presents a favorable surface for medical devices, particularly those involving blood contact.