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Related Experiment Videos

Experimental development of a fixed volume, gravity draining, prosthetic urinary bladder.

M J Gleeson1, S Anderson, C Homsy

  • 1Scott Department of Urology, Baylor College of Medicine, Texas Medical Center, Houston 77030.

ASAIO Transactions
|July 1, 1990
PubMed
Summary

Researchers developed a novel prosthetic urinary bladder for animals. This innovative design aims for urine containment and gravity drainage, addressing key challenges in bladder reconstruction.

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Area of Science:

  • Biomaterials Science
  • Urology
  • Surgical Innovation

Background:

  • Bladder reconstruction presents significant clinical challenges.
  • Current methods often face complications like infection and poor integration.
  • A need exists for advanced prosthetic urinary bladder solutions.

Purpose of the Study:

  • To develop and test a novel, fixed-volume, semi-rigid, gravity-draining prosthetic urinary bladder.
  • To evaluate critical design principles for a functional and durable artificial bladder.
  • To assess the biocompatibility and integration of the prosthesis in experimental animals.

Main Methods:

  • Development of a prosthetic bladder model with specific design criteria.
  • Testing of key components including encrustation-resistant surfaces and anastomoses.

Related Experiment Videos

  • In vivo implantation and evaluation in various animal models (rodents, rabbits, swine, dogs).
  • Utilized Biolor II and Proplast materials for fabricating prosthetic bladders in mini-swine.

    • Main Results:

    • Successfully tested the prosthetic bladder principles in multiple animal species.
    • Demonstrated feasibility of urothelial-prosthesis and bowel-prosthesis anastomoses.
    • Two alloplastic prosthetic bladders were implanted in mini-swine for a 4-week period.

    Conclusions:

    • The conceptual model for a prosthetic urinary bladder has been successfully tested in experimental animals.
    • The developed prosthesis addresses critical requirements for encrustation resistance, secure anastomoses, and bacterial resistance.
    • Further investigation and long-term studies are warranted for clinical translation.