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Related Experiment Video

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Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
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Published on: April 15, 2021

Age-dependent differences in cervical artery dissection.

Tiina M Metso1, Stéphanie Debette, Caspar Grond-Ginsbach

  • 1Department of Neurology, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 4, 00290, Helsinki, Finland.

Journal of Neurology
|April 25, 2012
PubMed
Summary
This summary is machine-generated.

Age influences cervical artery dissection (CeAD) presentation, with younger patients more likely to have vertebral artery dissection (VAD) and older patients internal carotid artery dissection (ICAD). Age is not a significant predictor of CeAD stroke outcomes.

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Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
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Published on: April 15, 2021

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Cervical artery dissection (CeAD) is a leading cause of stroke in young adults.
  • Age-dependent differences in CeAD presentation and risk factors are not well understood.

Purpose of the Study:

  • To investigate age-related variations in the characteristics and outcomes of cervical artery dissection (CeAD).
  • To compare younger and older CeAD patient groups.

Main Methods:

  • Retrospective analysis of 983 CeAD patients and 658 non-CeAD ischemic stroke (IS) controls.
  • Patients categorized into three age groups: ≤33, 34-54, and ≥55 years.
  • Comparison of clinical presentation, vascular risk factors, and outcomes between the youngest (≤33) and oldest (≥55) CeAD groups.

Main Results:

  • Younger CeAD patients were predominantly female with vertebral artery dissection (VAD), while older patients were predominantly male with internal carotid artery dissection (ICAD).
  • The frequency of transient ischemic events decreased with age in CeAD patients.
  • Vascular risk factors, particularly hypertension, increased with age, with a steeper rise in non-CeAD IS patients.
  • Preceding infection was more common in older CeAD patients.
  • Functional outcome (modified Rankin Scale) showed a trend towards better outcomes in younger non-CeAD IS patients, but not significantly in CeAD patients.

Conclusions:

  • Age is associated with specific patterns of CeAD, including artery involved (VAD vs. ICAD) and gender distribution.
  • Age-related differences in vascular risk factors and preceding infection exist between CeAD and non-CeAD IS groups.
  • Age does not appear to be a significant predictor of stroke outcome in CeAD.