Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated Analysis of Liquid Biopsy Using Deep Learning: Detecting Circulating Tumor Cells and Cancer-Associated Fibroblasts.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Personalized whole-genome-based ctDNA dynamics during neoadjuvant therapy across breast cancer subtypes: results from MONITOR-Breast.

Future oncology (London, England)·2026
Same author

A novel algae oil-based emulsion enhances chemotherapy outcome in human cancer models.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same author

Impact of voxelotor discontinuation on patients with sickle cell disease.

British journal of haematology·2026
Same author

Quantitative and qualitative patient-reported analysis of misdiagnosis and/or late diagnosis of metastatic lobular cancer.

medRxiv : the preprint server for health sciences·2026
Same author

Long-term prognostic value of ctDNA in early breast cancer: insights from the neoadjuvant ABCSG-34 Trial.

NPJ breast cancer·2026

Related Experiment Video

Updated: May 22, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

Size-based enrichment technologies for CTC detection and characterization.

Anthony Williams1, Marija Balic, Ram Datar

  • 1Department of Pathology, University of Miami-Miller School of Medicine, 1501 NW 10th Ave BRB 742, Miami, FL, 33132, USA. AWilliams12@med.miami.edu

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|April 25, 2012
PubMed
Summary

Detecting circulating tumor cells (CTCs) is key for cancer metastasis research. This study explores size-based methods for isolating rare CTCs from blood, comparing them to affinity-based techniques.

More Related Videos

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
10:12

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Related Experiment Videos

Last Updated: May 22, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
10:12

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Metastatic spread is a critical factor in cancer treatment decisions.
  • Circulating tumor cells (CTCs) are cells that enter the bloodstream and cause distant metastases.
  • The rarity of CTCs (as low as 1 per mL of blood) hinders their study and use as biomarkers.

Purpose of the Study:

  • To review and discuss technologies for isolating CTCs based on their size.
  • To compare the advantages and disadvantages of size-based CTC enrichment with affinity-based methods.

Main Methods:

  • Discussion of current and emerging size-based enrichment technologies for CTCs.
  • Comparative analysis of size-based versus affinity-based CTC enrichment platforms.

Main Results:

  • Size-based enrichment offers a viable approach to isolate rare CTCs.
  • Different size-based technologies present unique advantages and limitations.
  • Comparison highlights trade-offs between size-based and affinity-based enrichment strategies.

Conclusions:

  • Size-based enrichment is a promising strategy for overcoming CTC rarity.
  • Understanding the pros and cons of different enrichment methods is crucial for advancing CTC research.
  • Further development of size-based technologies could improve CTC biomarker applications.