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Updated: May 22, 2026

Analysis of Gene Function and Visualization of Cilia-Generated Fluid Flow in Kupffer's Vesicle
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Left-right asymmetry in zebrafish.

Takaaki Matsui1, Yasumasa Bessho

  • 1Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Nara, 630-0101, Japan. matsui@bs.naist.jp

Cellular and Molecular Life Sciences : CMLS
|April 25, 2012
PubMed
Summary

Left-right body asymmetry in vertebrates is crucial for organ placement. Recent zebrafish studies reveal how the Kupffer

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Area of Science:

  • Developmental biology
  • Genetics
  • Comparative anatomy

Background:

  • Vertebrate organ positioning is asymmetric across the left-right (LR) axis.
  • LR asymmetry is a conserved trait in the vertebrate body plan.
  • Embryonic development involves genetic mechanisms regulating LR asymmetry.

Purpose of the Study:

  • To summarize recent advances in understanding LR asymmetry.
  • To describe mechanisms of Kupffer's vesicle organizer region development.
  • To explain how LR asymmetry information is relayed to the lateral plate mesoderm.

Main Methods:

  • Review of recent zebrafish studies.
  • Analysis of genetic mechanisms in embryonic development.
  • Investigation of Kupffer's vesicle and lateral plate mesoderm interactions.

Main Results:

  • New insights into Kupffer's vesicle organizer region generation.
  • Understanding of LR asymmetry information relay mechanisms.
  • Detailed description of conserved genetic pathways.

Conclusions:

  • Zebrafish models provide critical insights into LR asymmetry.
  • Coordinated genetic mechanisms are essential for establishing LR asymmetry.
  • Further research continues to elucidate these developmental processes.

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Last Updated: May 22, 2026

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