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Updated: May 22, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
Published on: May 16, 2017
Developmental diseases caused by impaired nucleotide sugar transporters
1Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Evans-E438, 72 East Concord Street, Boston, MA 02118, USA.
Abstract:
Nucleotide sugar transporters play critical roles in glycosylation of proteins, lipids and proteoglycans, which are essential for organogenesis, development, mammalian cellular immunity and pathogenicity of human pathogenic agents. Functional deficiencies of these transporters result in global defects of glycoconjugates, which in turn lead to a diversity of biochemical, physiological and pathological phenotypes. In this short review, we will highlight human and bovine diseases caused by mutations of these transporters.
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