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Updated: May 22, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder
Dan J Stein1, Nastassja Koen, Naomi Fineberg
1University of Cape Town Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa. dan.stein@uct.ac.za
Abstract:
There is a need to synthesize the growing body of literature on the pharmacotherapeutic management of patients with obsessive-compulsive disorder for clinicians working at a primary care level. We have aimed to generate a simple, easy-to-follow algorithm for the primary care practitioner. This seven-step algorithm addresses diagnosis of obsessive-compulsive disorder, initiation of pharmacotherapy, monitoring and maintenance treatment, and guidelines for the management of patients who are resistant to initial therapy. In creating this algorithm, we have drawn on the body of published evidence, as well as on expert opinion.
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