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Related Experiment Video

Updated: May 22, 2026

Mouse In Vivo Placental Targeted CRISPR Manipulation
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REDD1 expression in placenta during human gestation.

Ya Yi Hu1, Ji Cheng Liu, Ai Yun Xing

  • 1Department of Obstetrics and Gynecology, The Second West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Reproductive Sciences (Thousand Oaks, Calif.)
|April 25, 2012
PubMed
Summary
This summary is machine-generated.

Regulated in development and DNA responses (REDD1) protein is elevated in human placentas during early gestation and in preeclampsia (PE). This suggests REDD1 is involved in placental function and PE development.

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Area of Science:

  • Reproductive biology
  • Cellular signaling
  • Pregnancy complications

Background:

  • The regulated in development and DNA responses (REDD1) protein plays a role in cellular stress responses.
  • Understanding placental development and its complications like preeclampsia (PE) is crucial for maternal and fetal health.

Purpose of the Study:

  • To investigate the expression of REDD1 in human placentas across different gestational ages (GAs).
  • To determine the correlation between REDD1 levels and preeclampsia (PE).

Main Methods:

  • REDD1 mRNA and protein expression were analyzed using immunohistochemistry, qRT-PCR, and Western blot.
  • Placental REDD1 protein levels were compared between normal pregnancies and PE pregnancies (early and late onset).

Main Results:

  • REDD1 protein was primarily localized in the cytoplasm of trophoblasts.
  • Higher REDD1 levels were observed in earlier gestational stages and in preeclampsia groups compared to normal pregnancies.
  • Significant differences were noted in REDD1 expression between normal and PE placentas (P < .05).

Conclusions:

  • REDD1 is expressed in human placenta and its levels change with gestational age.
  • Increased REDD1 expression is associated with preeclampsia, suggesting a role in its pathogenesis.
  • REDD1 may be important for maintaining normal placental function throughout gestation.