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Updated: May 22, 2026

Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
Cell-to-cell transmission of α-synuclein aggregates
Seung-Jae Lee1, Paula Desplats, He-Jin Lee
1Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea.
Abstract:
It is now recognized that the cell-to-cell transmission of misfolded proteins such as α-synuclein contributes to the neurodegenerative phenotype in neurological disorders such as idiopathic Parkinson's disease, Dementia with Lewy bodies, and Parkinson's disease dementia. Thus, establishing cell-based models for the transmission of α-synuclein is of importance to understand the mechanisms of neurodegeneration in these disorders and to develop new therapies. Here we describe methods to study the neuron-to-neuron propagation of α-synuclein in an in vitro setting that also has in vivo applications.
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