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Treatment options for severe hypertriglyceridemia (SHTG): the role of apheresis

Nils Ewald1, Hans-Ulrich Kloer

  • 1Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Klinikstr. 33, 35392 Giessen, Germany. nils.ewald@innere.med.uni-giessen.de

Clinical Research in Cardiology Supplements
|April 25, 2012
PubMed

Insights

Severe hypertriglyceridemia (SHTG) requires rapid triglyceride lowering. Plasmapheresis is a safe and effective treatment for SHTG, especially in emergencies like pancreatitis.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Medical Technology

Background:

  • Hypertriglyceridemia is linked to severe conditions like acute pancreatitis and coronary artery disease.
  • Severe hypertriglyceridemia (SHTG), defined as triglycerides > 1,000 mg/dL, necessitates prompt reduction of plasma triglycerides (TG).

Purpose of the Study:

  • To review the current literature on therapeutic apheresis for severe hypertriglyceridemia.
  • To evaluate the safety and efficacy of plasmapheresis in managing SHTG.

Main Methods:

  • Literature review of existing studies on apheresis for SHTG.
  • Analysis of plasmapheresis as a treatment modality for hypertriglyceridemic pancreatitis.

Main Results:

  • Plasmapheresis is identified as a safe and effective therapeutic option for SHTG.
  • Apheretic treatment can remove the causative factors of pancreatic inflammation.
  • Early intervention with apheresis appears to yield optimal outcomes.

Conclusions:

  • Plasmapheresis is a valuable tool for managing SHTG, particularly in acute settings.
  • The early application of apheresis is recommended for best results in SHTG management.
  • High costs and limited availability restrict the widespread use of plasmapheresis.

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