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Related Experiment Video

Updated: May 22, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Detecting and characterizing individual molecules with single nanopores.

John J Kasianowicz1, Joseph E Reiner, Joseph W F Robertson

  • 1Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA. john.kasianowicz@nist.gov

Methods in Molecular Biology (Clifton, N.J.)
|April 25, 2012
PubMed
Summary

Single-nanometer pores enable molecule detection and characterization. Further understanding of nanopore-analyte interactions is crucial for advancing this technology in healthcare and basic sciences.

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Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Biophysics

Background:

  • Single-nanometer-scale pores offer advanced capabilities for individual molecule analysis.
  • Existing commercial instrumentation could be expanded, and niche applications addressed by nanopore technology.
  • A deeper understanding of nanopore-analyte physics and chemistry is needed.

Purpose of the Study:

  • To investigate the fundamental physics and chemistry governing interactions between nanopores and analytes.
  • To develop methods and approaches for enhanced understanding of nanopore-analyte interactions.
  • To facilitate the advancement of nanopore-based detection and characterization technologies.

Main Methods:

  • Detailed analysis of molecular interactions within single-nanometer pores.

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High Resolution Physical Characterization of Single Metallic Nanoparticles
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High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

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Last Updated: May 22, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

  • Development of novel experimental and computational approaches.
  • Characterization of the physical and chemical forces at the nanopore-analyte interface.

    • Main Results:

    • Our methods provide new insights into the governing principles of nanopore-analyte interactions.
    • We demonstrate approaches to enhance the understanding of these complex phenomena.
    • The findings lay the groundwork for improved nanopore-based analytical techniques.

    Conclusions:

    • Advancing the understanding of nanopore-analyte interactions is key to unlocking the full potential of this technology.
    • The described methods offer a pathway to improved molecular detection, identification, and characterization.
    • This research supports the integration of nanopore technology into broader scientific and healthcare applications.