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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Passive and electrically actuated solid-state nanopores for sensing and manipulating DNA.

Zhijun Jiang1, Mirna Mihovilovic, Erin Teich

  • 1Department of Physics, Brown University, Providence, RI, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 25, 2012
PubMed
Summary

Solid-state nanopores offer a new way to electrically analyze single DNA molecules. Researchers detail methods for fabricating these nanopores and integrating electrodes to control DNA translocation and ionic conductance.

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Area of Science:

  • Nanotechnology
  • Molecular Biology
  • Electrical Engineering

Background:

  • Solid-state nanopores are emerging as advanced tools for single DNA molecule electrical characterization.
  • Electrophoretic translocation of DNA through nanopores generates ionic current blockages, revealing molecular length and conformation.
  • Integration of nanofabricated actuators and sensors, like gate electrodes, can enhance nanopore functionality.

Purpose of the Study:

  • To describe detailed methods for fabricating passive solid-state nanopores.
  • To outline procedures for using these nanopores to detect DNA translocations.
  • To detail the integration of electrodes for creating electrically active nanopore structures and modulating ionic conductance.

Main Methods:

  • Fabrication of passive solid-state nanopores.
  • Detection of DNA translocations using fabricated nanopores.
  • Integration of electrodes (gate, tunneling) into nanopore membranes.
  • Modulation of ionic conductance via embedded annular gate electrodes.

Main Results:

  • Successful fabrication of solid-state nanopores for DNA analysis.
  • Demonstration of DNA translocation detection via ionic current measurements.
  • Creation of electrically active nanopore structures with integrated electrodes.
  • Control over ionic conductance through the nanopore using an embedded gate electrode.

Conclusions:

  • Detailed methods for fabricating and utilizing solid-state nanopores for DNA characterization are presented.
  • Electrically active nanopore structures with integrated electrodes offer enhanced functionality for DNA analysis.
  • The embedded annular gate electrode provides a means to actively modulate ionic conductance during DNA translocation.