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Updated: May 22, 2026
14:28
Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
HIV and inflammation: mechanisms and consequences.
1UCSF Positive Health Program, San Francisco, CA 94110, USA. phunt@php.ucsf.edu
Current HIV/AIDS Reports
|April 25, 2012
Summary
Persistent immune activation in HIV patients on antiretroviral therapy (ART) remains a challenge, predicting serious health issues. Understanding its causes, like HIV expression and microbial translocation, is key for new treatments.
Area of Science:
- Immunology
- Virology
- Public Health
Background:
- Persistent immune activation and inflammation are significant challenges in the modern HIV treatment era, even with effective antiretroviral therapy (ART).
- Elevated immune activation, inflammatory, and coagulation markers during suppressive ART predict increased mortality and non-AIDS morbidities, including cardiovascular disease.
Purpose of the Study:
- To review current knowledge on the causes of persistent immune activation during ART-mediated viral suppression.
- To summarize the link between persistent immune activation and morbidity/mortality in HIV-infected individuals on ART.
Main Methods:
- Review of recent scientific literature and studies.
- Analysis of data linking surrogate markers of inflammation to clinical outcomes.
- Examination of factors contributing to persistent inflammation, including HIV expression, microbial translocation, and co-infections.
Main Results:
- Persistent immune activation markers are validated therapeutic targets due to their link to clinical outcomes.
- Recent research clarifies the roles of persistent HIV expression/replication, microbial translocation, and co-infections in driving inflammation.
Conclusions:
- Persistent immune activation during ART is a critical issue impacting HIV patient health.
- Identifying the drivers of this inflammation is crucial for developing novel therapeutic interventions.
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