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Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell lines
Hai-Ying Ma1, Hui-Yuan Gao, Jian Huang
1Pharmacy Department, The Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan Eastern Road, Yuhong District, Shenyang 110032, China. cmu4h-mhy@126.com
Abstract:
Three new triterpenoid derivatives, 3-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (1), 3-formyloxy-20-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (2) and 26-hydroxyl-24(E)-20(S)-protopanaxtriol (3), along with six known ginsenosides, were isolated from leaves of Panax ginseng. Their structures were established on the basis of spectral analysis (IR, 1D and 2D NMR, HRESI-MS). Compounds 1-3 exhibited various degree of cytotoxicity towards human A549 pulmonary carcinoma cells and Hep3B hepatoma cells.