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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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A Simple Fecal Flotation Method for Diagnosing Zoonotic Nematodes Under Field and Laboratory Conditions
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Published on: December 15, 2023

Cutaneous toxoplasmosis in two dogs.

Aline Rodrigues Hoffmann1, Jennifer Cadieu, Matti Kiupel

  • 1Department of Veterinary Pathobiology, College of Veterinary Medicine, MS4467 Texas A&M University, College Station, TX 77843, USA. arodrigues@cvm.tamu.edu

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|April 25, 2012
PubMed
Summary

Cutaneous toxoplasmosis, a rare skin infection in dogs, can occur in immunosuppressed animals. This study details two canine cases, highlighting varied clinical signs and treatment outcomes with clindamycin.

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Last Updated: May 22, 2026

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06:33

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Published on: December 9, 2014

Area of Science:

  • Veterinary Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Cutaneous toxoplasmosis is infrequently documented in domestic animals, with limited reports in dogs, often associated with systemic disease.
  • This study focuses on two canine cases of cutaneous toxoplasmosis, specifically in dogs undergoing immunosuppressive therapy, a potential predisposing factor.

Observation:

  • Clinical presentations varied, including generalized pustules and pruritus in one dog and a solitary subcutaneous nodule in the other.
  • Histopathological examination revealed severe pyogranulomatous and necrotizing dermatitis and panniculitis, characterized by vasculitis and thrombosis.
  • Protozoal tachyzoites of *Toxoplasma gondii* were identified within inflammatory cells and tissues.

Findings:

  • Immunohistochemistry and PCR assays confirmed *Toxoplasma gondii* as the causative agent in both canine patients.
  • Treatment with clindamycin was initiated for both dogs.
  • Prognosis differed significantly: one dog experienced systemic complications and was euthanized, while the other with a single lesion achieved a full recovery.

Implications:

  • This report expands the understanding of cutaneous toxoplasmosis manifestations in dogs, particularly in immunosuppressed individuals.
  • It underscores the importance of considering *Toxoplasma gondii* in the differential diagnosis of canine dermatological conditions.
  • The varied clinical outcomes emphasize the need for further research into prognostic factors and optimal therapeutic strategies for canine toxoplasmosis.