Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stimulants01:29

Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Cholinergic Receptors: Nicotinic01:15

Cholinergic Receptors: Nicotinic

Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-pregnancy depression, prenatal care, and e-cigarette/cigarette use during late pregnancy among adolescents.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

Effects of nicotine concentration and pH on nicotine pouch appeal and sensory experience: A randomized experimental study.

Addiction (Abingdon, England)·2026
Same author

The impact of vaping and smoking on nicotine intake and toxicant exposure among youth in England compared with youth in North America.

Public health research (Southampton, England)·2026
Same author

Effects of nicotine form and tobacco flavor on pharmacokinetics, subjective effects, and behavioral indicators of abuse liability of e-cigarettes.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2026
Same author

Vaping and smoking trajectories among youth and adults in the United States across the period 2014-2022.

Frontiers in public health·2026
Same author

Vaping Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC) in liquid forms: pharmacokinetics, pharmacodynamics, and regulatory implications.

Expert review of clinical pharmacology·2026

Related Experiment Video

Updated: May 22, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

Nicotine levels in electronic cigarettes.

Maciej L Goniewicz1, Tomasz Kuma, Michal Gawron

  • 1Department of General and Analytical Chemistry, School of Pharmacy and Laboratory Medicine, Medical University of Silesia, Sosnowiec, Poland. m.goniewicz@qmul.ac.uk

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
|April 25, 2012
PubMed
Summary

Electronic cigarettes (ECs) deliver nicotine vapor, but nicotine levels vary significantly by brand and model. Effective ECs vaporize nicotine consistently, with lower inhaled amounts per puff than conventional cigarettes.

More Related Videos

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
09:30

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

Related Experiment Videos

Last Updated: May 22, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
09:30

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol

Published on: January 18, 2018

Area of Science:

  • Tobacco Harm Reduction
  • Analytical Chemistry
  • Public Health

Background:

  • Electronic cigarettes (ECs) are novel devices designed to deliver nicotine vapor, mimicking conventional cigarettes.
  • Limited data exists regarding the safety and nicotine delivery efficacy of ECs.
  • Understanding nicotine vaporization dynamics is crucial for assessing ECs' potential as a smoking alternative.

Purpose of the Study:

  • To analyze nicotine levels in vapor generated from various electronic cigarette brands and models.
  • To assess the efficacy and consistency of nicotine vaporization across different EC devices.
  • To investigate the dynamics of nicotine vaporization during EC use.

Main Methods:

  • Sixteen popular electronic cigarette brands and models were selected from Polish, U.K., and U.S. markets.
  • An automated smoking machine simulated real-world puffing conditions for vapor generation.
  • Nicotine content in the vapor was quantified using gas chromatography after absorption in methanol.

Main Results:

  • Nicotine levels in vapor ranged from 0.5 to 15.4 mg per 15 puffs across different ECs.
  • Most ECs demonstrated effective nicotine delivery for the initial 150–180 puffs.
  • An average of 50%-60% of the nicotine from a cartridge was vaporized during use.

Conclusions:

  • Electronic cigarettes produce nicotine-containing vapor, with significant variations in vaporization efficacy and consistency among brands and models.
  • ECs that effectively vaporize nicotine deliver lower amounts per 15 puffs compared to conventional cigarettes.
  • Further research is needed to fully understand the public health implications of electronic cigarette use.