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Related Experiment Videos

Overview of selected basic research in autism.

L R Piggott

    Journal of Autism and Developmental Disorders
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Research suggests autism may stem from various physiological disturbances, potentially overlapping with other developmental disorders. Objective markers are crucial for identifying distinct subgroups within autism for further investigation.

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    Area of Science:

    • Neurodevelopmental Disorders
    • Autism Spectrum Disorder Research
    • Physiological Basis of Disease

    Background:

    • Autism research indicates potential unique physiological disturbances, though evidence remains inconclusive.
    • Some identified physiological disturbances in autistic children also appear in other developmental disorders.
    • Autism may represent a complex of similar clinical manifestations arising from diverse underlying physiological disturbances.

    Purpose of the Study:

    • To review basic research on the physiological underpinnings of autism.
    • To highlight the need for objective markers to differentiate autism subgroups.
    • To explore potential objective markers for autism subtyping.

    Main Methods:

    • Review of existing basic research on autism and related physiological findings.

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  • Analysis of indications for unique and shared physiological disturbances.
  • Identification of potential objective biological markers.

    • Main Results:

    • Mounting evidence suggests physiological disturbances are linked to autism etiology.
    • Overlap exists between physiological disturbances in autism and other developmental disorders.
    • Several potential objective markers are proposed, including nystagmus duration, auditory evoked responses, immune response, and specific biochemicals.

    Conclusions:

    • Autism likely comprises distinct subgroups with different physiological disturbances, or a single disturbance affecting multiple systems.
    • Objective markers are essential for precise subgroup demarcation and targeted research.
    • Further investigation into proposed markers like postrotatory nystagmus, auditory evoked responses, and specific biochemicals is warranted.