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Cellulitis with leukocytopenia as an initial sign of acute promyelocytic leukemia
Sachiko Sakamoto1, Naoki Oiso, Masakatsu Emoto
1Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
Abstract:
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression. Acute promyelocytic leukemia (acute myeloid leukemia M3) is caused by translocation of reciprocal chromosomal rearrangement t(15;17), which produces an oncogenic protein. We herein describe a 71-year-old man having cellulitis with leukocytopenia as a first sign of acute promyelocytic leukemia. Dermatologists and hematologists should keep in mind that patients with a hematologic malignancy, such as acute promyelocytic leukemia, can develop cellulitis with leukocytopenia.
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