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Updated: May 22, 2026
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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Cutaneous lymphadenoma: a case report and immunohistochemical study
Taku Fujimura1, Aya Itoigawa, Takahiro Haga
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Case Reports in Dermatology
|April 25, 2012
Summary
This study investigates the cellular composition of cutaneous lymphadenoma, a rare skin tumor. Immunohistochemistry revealed specific T cell subsets and BerEP4-positive cells within the tumor, offering new insights into its pathology.
Area of Science:
- Oncology
- Dermatopathology
- Immunohistochemistry
Background:
- Cutaneous lymphadenoma is a rare neoplasm characterized by significant mononuclear cell infiltration.
- Previous studies suggested T cells and Langerhans cells comprise the infiltrate, but detailed phenotypical analysis was lacking.
Observation:
- A case of cutaneous lymphadenoma in a 70-year-old Japanese patient was analyzed.
- Immunohistochemical staining was employed to examine tumor-infiltrating cells, focusing on T cell subsets.
- Abundant mucin deposits and BerEP4-positive cells in tumor lobules were noted.
Findings:
- The study provides the first detailed immunohistochemical analysis of T cell subsets within cutaneous lymphadenoma.
- Specific T cell profiles and the presence of BerEP4-positive cells were identified as key components of the tumor.
Implications:
- This research enhances the understanding of cutaneous lymphadenoma's cellular makeup.
- The findings may guide future diagnostic approaches and therapeutic strategies for this rare skin neoplasm.
