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Related Experiment Video

Updated: May 22, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Inflammation and cancer.

Noemí Eiró¹, Francisco J Vizoso

¹Noemí Eiró, Francisco J Vizoso, Research Unit, Fundación Hospital de Jove, 33290 Gijón, Asturias, Spain.

World Journal of Gastrointestinal Surgery

|April 25, 2012

Summary

This summary is machine-generated.

Chronic inflammation creates conditions conducive to cancer development by disrupting the cellular microenvironment and promoting tumor growth. Targeting the interplay between inflammation and the tumor microenvironment offers potential for novel anticancer therapies.

Keywords:

Cancer Cancer progression Cytokines Inflammation Metastasis Proliferation

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Last Updated: May 22, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Area of Science:

Oncology
Immunology
Cell Biology

Background:

Inflammation plays a critical role in cancer development by altering the cellular microenvironment.
Dysregulated immune responses can lead to persistent inflammation, affecting cancer-related genes and protein modifications.
Tumor-infiltrating leukocytes and mediators within the tumor microenvironment influence cancer progression and metastasis.

Purpose of the Study:

To explore the dual role of inflammation in cancer, encompassing both promotion and potential therapeutic targeting.
To investigate how unresolved inflammation impacts cellular processes crucial for cancer development.
To examine the influence of inflammatory cells and mediators on tumor progression and metastasis.

Main Methods:

Review of existing scientific literature and evidence.
Analysis of data on the molecular and cellular mechanisms linking inflammation and cancer.
Examination of the role of tumor-infiltrating leukocytes and their secreted factors.

Main Results:

Unresolved inflammation perturbs the cellular microenvironment, altering genes and proteins involved in cell cycle, DNA repair, and apoptosis.
Inflammatory cells and mediators within the tumor microenvironment can promote tumor progression, angiogenesis, growth, and invasion.
Cytokines, growth factors, chemokines, and proteases secreted by inflammatory cells stimulate cancer cell proliferation and invasiveness.

Conclusions:

The cross-talk between the tumor microenvironment and inflammatory processes is a significant factor in cancer development.
Inflammatory cells, initially viewed as a defense mechanism, can actively promote tumor phenotypes.
Targeting the molecular events and molecules involved in this inflammatory-cancer crosstalk presents promising avenues for anticancer therapeutic interventions.