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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Castration-resistant prostate cancer: mechanisms, targets, and treatment

Teresa Maria Santos Amaral1, Daniela Macedo, Isabel Fernandes

  • 1Oncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, Portugal.

Prostate Cancer
|April 25, 2012
PubMed

Insights

New treatments offer hope for castration-resistant prostate cancer (CRPC) patients progressing after docetaxel. Research advances provide a better understanding of CRPC mechanisms and new therapeutic targets.

Area of Science:

  • Oncology
  • Urology

Background:

  • Castration-resistant prostate cancer (CRPC) presents limited therapeutic options for patients progressing after docetaxel therapy.
  • Recent molecular, basic, and translational research has improved understanding of CRPC mechanisms.

Purpose of the Study:

  • To review the mechanisms of prostate cancer resistance.
  • To discuss potential therapeutic targets for CRPC.
  • To present new treatment options for CRPC.

Main Methods:

  • Literature review of recent advances in prostate cancer research.
  • Analysis of emerging therapeutic strategies for CRPC.

Main Results:

  • New therapeutic options are emerging for CRPC patients.
  • These include inhibitors of androgen biosynthesis, novel chemotherapy, bone-targeted therapy, and immunotherapy.
  • A better understanding of CRPC mechanisms facilitates a rational drug development approach.

Conclusions:

  • Advances in research have expanded treatment possibilities for CRPC.
  • New therapies offer improved prospects for patients with advanced prostate cancer.

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