Related Experiment Video
Updated: May 22, 2026

Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
Hemostatic matrix application after open synovectomy in a hemophilic patient
Manuel García Aríz1, Omar Pérez-Carrasquillo, Charles E Zierenberg
1Department of Orthopaedic Surgery, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico. manuel.garcia8@upr.edu
Abstract:
Recurrent, spontaneous bleeding is common in patients with hemophilia. The joints are commonly and repeatedly affected, and this can result in chronic synovitis and joint damage. Synoviorthesis or synovectomy are indicated after failure of appropriate medical management. Hemostasis in the perioperative period is paramount in these patients. We report a case study of a patient with hemophilia A inhibitors undergoing open synovectomy complicated by postoperative bleeding. In addition to an infusion of bypassing agents due to the presence of inhibitors, a topical hemostatic agent, FLOSEAL, and absorbable Gelfoam were applied. Hemostasis was achieved rapidly. The patient recovered without complications.
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Vascular Spasm
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis IV: Nursing Management