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Updated: May 22, 2026
04:20
A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
Published on: July 28, 2020
Management of bleeding disorders in adults
F Peyvandi1, R Klamroth, M Carcao
1U.O.S. Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione I.R.C.C.S. Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano and Luigi Villa Foundation, Milan, Italy. flora.peyvandi@unimi.it
Summary
Developing inhibitors to Factor VIII (FVIII) is a major challenge in haemophilia A treatment, incurring significant costs. Research focuses on optimizing therapies for this chronic condition and its complications.
Area of Science:
- Haematology
- Clinical Research
- Treatment Optimization
Background:
- Factor VIII (FVIII) inhibitors are a severe complication of haemophilia A treatment.
- This complication poses a significant economic burden for managing this chronic disease.
Purpose of the Study:
- To review key aspects of adult haemophilia management.
- To provide an update on current research and treatment strategies for haemophilia A.
Main Methods:
- Review of clinical research efforts to optimize therapeutic approaches.
- Analysis of FVIII consumption, prophylaxis, and economic data from relevant studies (RES.I.ST, Pro.Will, PROFIT).
Main Results:
- Discussion encompasses bleeding in von Willebrand disease, FVIII consumption patterns, and the RES.I.ST study update.
- Includes insights into long-term prophylaxis, Pro.Will study findings, and economic aspects from the PROFIT study.
Conclusions:
- Management of haemophilia in adults requires a comprehensive approach, addressing inhibitors, bleeding disorders, and musculoskeletal complications.
- Ongoing research and data analysis are crucial for optimizing treatment and reducing the economic impact of haemophilia.
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