Related Experiment Video
Updated: May 22, 2026
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Stoichiometric self-assembly of isomeric, shape-persistent, supramacromolecular bowtie and butterfly structures
Anthony Schultz1, Xiaopeng Li, Balaka Barkakaty
1Department of Chemistry, The University of Akron, Akron, Ohio 44325, USA.
Abstract:
Two novel macromolecular constitutional isomers have been self-assembled from previously unreported terpyridine ligands in a three-component system. The terpyridine ligands were synthesized in high yields via a key Suzuki coupling. Restrictions of the possible outcomes for self-assembly ultimately provided optimum conditions for isolation of either a molecular bowtie or its isomeric butterfly motif. These isomers have been characterized by ESI-MS, TWIM-MS, (1)H NMR, and (13)C NMR. Notably, these structural isomers have remarkably different drift times in ion mobility separation, corresponding to different sizes and shapes at high charge states.
Related Concept Videos
02:41Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
02:11Conformations of Cyclohexane
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...
01:18Assembly of Cytoskeletal Filaments