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Spray drying of monodispersed microencapsulates: implications of formulation and process parameters on
Wenjie Liu1, Winston Duo Wu, Cordelia Selomulya
1Department of Chemical Engineering, Monash University, Australia.
Journal of Microencapsulation
|April 26, 2012
Summary
Uniform silica microparticles were created using microfluidic jet spray drying for controlled drug delivery. This method precisely controls particle properties, enabling tailored drug release functionalities for pharmaceutical applications.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Chemical Engineering
Background:
- Pharmaceutical particulates demand precise control over characteristics for optimal therapeutic outcomes.
- Conventional spray drying often results in broad particle size distributions, complicating property analysis.
- Microfluidic techniques offer potential for generating uniform particles with controlled properties.
Purpose of the Study:
- To demonstrate the precise control over silica particle characteristics using microfluidic jet spray drying.
- To investigate the influence of formulation and process parameters on drug encapsulation and release.
- To establish a method for designing spray-dried microencapsulates with tailor-made controlled release.
Main Methods:
- Utilized a microfluidic jet spray drying technique to generate uniform silica particles encapsulating model drugs.
- Incorporated lactose into formulations to modify internal particle microstructures and regulate drug release.
- Adjusted drying temperature during synthesis to modify particle surface features.
- Analyzed the impact of drug physicochemical properties and precursor pH on particle morphology and release profiles.
Main Results:
- Achieved uniform spray-dried silica particles with controlled characteristics, avoiding issues of conventional methods.
- Demonstrated that lactose incorporation effectively modified internal structures for regulated drug release.
- Showed that increased drying temperature altered particle surface features.
- Confirmed that drug properties influenced particle morphology and release, while precursor pH affected morphology and initial release rates.
Conclusions:
- Microfluidic jet spray drying provides a robust platform for producing uniform silica microparticles for pharmaceutical applications.
- Formulation and process parameters can be precisely manipulated to achieve desired particle characteristics and controlled drug release profiles.
- This approach facilitates the rational design of silica-based microencapsulates with customized therapeutic functionalities.
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