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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Updated: May 22, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Sarcopenia in the elderly: basic and clinical issues.

Cuiying Wang1, Li Bai

  • 1Medical Health Center of Beijing Friendship Hospital of Capital Medical University, Beijing, China.

Geriatrics & Gerontology International
|April 26, 2012
PubMed
Summary
This summary is machine-generated.

Sarcopenia, the age-related loss of muscle mass, affects 5-13% of adults aged 60-70 and over 50% of those 80+. This review highlights its definition, prevalence, and management to improve clinical recognition and treatment.

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Public Health

Background:

  • Sarcopenia is defined as age-related muscle mass loss.
  • Prevalence increases significantly with age, affecting 5-13% of 60-70 year olds and 11-50% of those 80+.
  • The global population of older adults is rapidly increasing, highlighting the public health significance of age-related conditions like sarcopenia.

Purpose of the Study:

  • To review the definition, prevalence, and symptoms of sarcopenia in older adults.
  • To discuss pharmacy and physical therapy interventions for sarcopenia.
  • To promote clinical recognition and treatment of age-related sarcopenia.

Main Methods:

  • Literature review focused on sarcopenia definition, prevalence, and management.
  • Analysis of existing data on age-related muscle mass changes.
  • Synthesis of information on clinical recognition and treatment strategies.

Main Results:

  • Sarcopenia prevalence is substantial and increases with advanced age.
  • Limited data exists on serial muscle mass changes and their health consequences.
  • Effective pharmacy and physical therapy interventions are crucial for management.

Conclusions:

  • Age-related sarcopenia is a growing concern due to demographic shifts.
  • Further research is needed on the longitudinal changes in muscle mass and associated adverse outcomes.
  • Enhanced clinical recognition and integrated treatment approaches are essential for addressing sarcopenia in older populations.