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Emerging drugs for cervical cancer
Alfonso Dueñas-Gonzalez1, Lucely Cetina, Jaime Coronel
1Division of Clinical Research, Instituto Nacional de Cancerología-México (INCan), Mexico City, Mexico. alfonso_duenasg@yahoo.com
Expert Opinion on Emerging Drugs
|April 26, 2012
Summary
Developing new treatments for advanced cervical cancer is crucial. Emerging therapies targeting HPV oncogenes show promise, but require further research for effective delivery and development of inhibitors.
Area of Science:
- Oncology
- Gynecologic Oncology
- Cancer Therapeutics
Background:
- Limited therapeutic options exist for advanced invasive cervical cancer.
- Cervical cancer treatment has seen modest survival gains with cisplatin doublets and improved rates with chemoradiation for locally advanced disease.
- Significant unmet needs remain in developing novel agents for late-stage cervical cancer.
Purpose of the Study:
- To review current achievements in cervical cancer treatment.
- To highlight emerging therapeutic agents and their developmental phases.
- To identify key molecular targets and future research directions for cervical cancer.
Main Methods:
- Literature search on PubMed and related databases for cervical cancer information.
- Review of current and emerging therapeutic agents.
- Focus on agents in early and late phases of development.
Main Results:
- Cisplatin doublets offer modest survival gains in advanced disease.
- Chemoradiation improves survival in locally advanced cervical cancer.
- Anti-VEGF and anti-EGFR monoclonal antibodies are in late-phase development.
- Numerous miscellaneous agents are in early development stages.
Conclusions:
- Targeting HPV-E6/E7 oncogenes represents a promising strategy for cervical cancer.
- Development of effective delivery systems for nucleic acid-based therapies is essential.
- Further research is needed to develop small-molecule inhibitors targeting E6/E7 or related proteins.
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