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Translating TRAIL-receptor targeting agents to the clinic

Martha W den Hollander1, Jourik A Gietema, Steven de Jong

  • 1Department of Medical Oncology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

Cancer Letters
|April 26, 2012
PubMed
Summary

Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) activates the extrinsic apoptotic pathway for cancer treatment. Clinical studies show TRAIL-based therapies are safe and well-tolerated, with future research focusing on patient selection biomarkers.

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